How is Chantix®® different from other stop-smoking aids?

When you smoke, the nicotine from your cigarette causes receptors in your brain to release a chemical called dopamine, which is what causes many of the positive feelings you get when you smoke. When you quit smoking, going without dopamine causes the sometimes miserable signs and symptoms of withdrawal. Signs and symptoms such as irritability, insomnia and difficulty concentrating begin four to six hours after your last cigarette and can last a month after you quit smoking.

Chantix® works in this way, too. Chantix® stimulates the release of low levels of dopamine in your brain to help reduce the signs and symptoms of withdrawal. In addition, Chantix® blocks nicotine receptors in your brain. So if you lapse and have a cigarette, your cigarette doesn't stimulate your brain's receptors the way it did in the past. Cigarettes become much less pleasurable, and your desire to return to regular smoking again may be reduced.

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How do you take Chantix®?

For best results, it's recommended that you start taking Chantix® a week before your quit date. Doctors prescribe the pill for 12 weeks — once a day at first, then twice a day. Gradually increasing the dose helps reduce the chance of side effects. If you've remained smoke-free after 12 weeks, your doctor may consider prescribing an additional 12 weeks of Chantix® to improve your chances of remaining smoke-free.

Note: Be sure to tell your doctor about any history of psychiatric illness before taking Chantix®. Chantix® may worsen a psychiatric illness even if it's currently under control. It may also cause an old psychiatric illness to recur

The Food and Drug Administration (FDA) issued an advisory in 2008 that healthcare professionals, patients, patients' families and caregivers should be alert to and monitor for changes in mood and behavior in people taking Chantix®. Symptoms may include anxiety, nervousness, tension, depressed mood, unusual behaviors and thinking about or attempting suicide. People taking Chantix® should report changes in mood and behavior to their doctor immediately. The FDA also advises that people taking Chantix® may experience impaired ability to drive or operate heavy machinery.

Don't take Chantix® if you're pregnant or are planning to become pregnant, or if you're breast-feeding. Chantix® hasn't been studied in these situations, so it isn't clear if it's safe for these women.

People with kidney problems and those on dialysis may need to have a lower dose of Chantix®, so discuss this with your doctor.

Quitting smoking may alter the effects of certain medications and supplements on your body. Tell your doctor about all the medications and supplements you're taking, especially if you're taking inhaled insulin, asthma medicines or blood thinners.

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